Ribose Health Topic
Learn More About Ribose
It is known that during high intensity exercise, ATP is depleted in the heart and skeletal muscles. Since D-ribose is used to synthesize nucleotides, the building blocks of ATP, it is theorized that supplementation with D-ribose will increase the rate at which ATP is restored and therefore increase energy. D-ribose is a naturally occurring organic compound. It is the backbone of RNA (ribonucleic acid), which is responsible for genetic transcription (the process by which genetic material is exchanged).
The Use of D-Ribose in Chronic Fatigue Syndrome and Fibromyalgia: A Pilot Study
D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle. Approximately 66% of patients experienced significant improvement while on D-ribose. D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.
D-Ribose is Taken by Athletes and Autoimmune Patients to Restore Energy
D-ribose is a naturally occurring sugar that enhances energy by generating recovery of ATP levels (your body's primary energy carrying molecule).
D-Ribose Aids Advanced Ischemic Heart Failure Patients
Ribose, a pentose monosaccharide, has shown to replenish low myocardial energy levels, improving cardiac dysfunction following ischemia, and improving ventilation efficiency in patients with heart failure. Ribose improved the ventilatory exercise status in advanced heart failure patients.
D-Ribose in Congestive Heart Failure and Ischemic Disease (pdf)
Ribose is a substrate that regulates and controls the synthesis of energy compounds. Ribose is an integral component of the ATP molecule and regulates its synthesis. Most tissues in the body, including the heart, are unable to produce ribose fast enough to quickly restore energy levels once they are depleted. Ribose is made naturally in the body from the simple sugar, glucose. The metabolic pathway used to make ribose naturally is slow and inefficient because these tissues lack certain enzymes required to drive the pathway. Providing exogenous ribose to these tissues is proven to enhance their ability to normalize energy pools once they have been reduced or depleted. Ischemia or hypoxia severely depress cardiac energy levels. Immediately following ischemia, hearts that are given ribose rapidly re-build their energy pool. In a trial with congestive heart failure patients, results showed conclusively that when patients were given ribose they had improved diastolic heart function, increased physical function score and enhanced quality of life score.
Use of Ribose to Prevent Cramping and Soreness in Muscles
Ribose administered before exercise reduces or prevents exercise-induced muscle cramping and soreness. Ribose taken both before and immediately after exercise further reduces or prevents exercise-induced muscle cramping and soreness.During muscle contraction, oxygen demand may exceed oxygen availability, that is, the muscle may become hypoxic. In exercising, hypoxic muscle, energy production switches from the aerobic to anaerobic production of adenosine triphosphate (ATP). Anaerobic energy production from glucose, that is, glycolysis, produces lactic acid as an end product. At the same time, ATP breaks down to form inosine and hypoxanthine, the further metabolism of which results in the formation of free-radicals, very reactive molecules that can cause cellular damage. The presence of ribose during a hypoxic event can raise the hypoxic threshold in persons encountering situations of low oxygen availability.
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