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Manganese Health Topic

Manganese Health Topic

Manganese activates enzymes involved in utilization of several key nutrients and in the metabolism of proteins, amino acids, cholesterol, and carbohydrates. Manganese is also important for reproductive health and bone formation. In animal studies, manganese deficiency results in abnormal skeletal development. Women with osteoporosis have decreased plasma levels of manganese. Low levels of manganese are also associated with glucose intolerance similar to diabetes mellitus, increased seizure susceptibility, and multiple sclerosis. The ratio of iron to manganese in the body is important for maintaining optimum iron levels. In vitro research has indicated that increased cellular manganese slows the activity of a key enzyme, reverse transcriptase, necessary for HIV replication.

Dietary Sources of Manganese:
Mustard greens, kale, chard, raspberries, pineapple, romaine lettuce, spinach, collard greens, turnip greens, kale, maple syrup, molasses, garlic, grapes, summer squash, strawberries, oats, spelt, green beans, brown rice, garbanzo beans, ground cloves, cinnamon, thyme, peppermint, and turmeric.

Note: encourages personal research and a balanced view of health and nutrition topics. The links below provide a broad overview of various research findings and hypothesis on the role of nutrition in health. This information is not intended to promote any particular product. Unless noted, the articles below do not include any scientific references.

Learn More About Manganese

  1. Manganese Blocks HIV Replication; Lab Finding Points to Potential New Class of HIV Treatments

    Johns Hopkins scientists have found that simply increasing manganese in cells can halt HIV's unusual ability to process its genetic information backwards, providing a new way to target the process's key driver, an enzyme called reverse transcriptase. Retroviruses like HIV use reverse transcriptase to make copies of their DNA from RNA, the opposite of how genetic information is usually processed in cells.


  2. Manganese on World's Healthiest Foods

    In the human body, manganese functions as an enzyme activator. Manganese activates the enzymes responsible for the utilization of several key nutrients including biotin, thiamin, ascorbic acid, and choline. It is a catalyst in the synthesis of fatty acids and cholesterol, facilitates protein and carbohydrate metabolism, and may also participate in the production of sex hormones and maintaining reproductive health. In addition, manganese activates enzymes which are important in the formation of bone.


  3. Manganse on Linus Pauling Institute

    A number of manganese-activated enzymes play important roles in the metabolism of carbohydrates, amino acids, and cholesterol. Manganese deficiency results in abnormal skeletal development in a number of animal species. Manganese is required for the activation of prolidase, an enzyme that functions to provide the amino acid, proline, for collagen formation in human skin cells. It has been documented that women with osteoporosis have decreased plasma levels of manganese. Manganese deficiency results in glucose intolerance similar to diabetes mellitus in some animal species. Manganese deficient rats are more susceptible to seizures than manganese sufficient rats, and rats that are genetically prone to epilepsy have lower than normal brain and blood manganese levels.


  4. Manganese, Copper, and Zinc in Cerebrospinal Fluid from Patients with Multiple Sclerosis

    Manganese levels were significantly decreased in the cerebrospinal fluid of Multiple Sclerosis patients compared to the levels in the control group. Copper levels were significantly elevated in Multiple Sclerosis patients.


  5. Manganese-Containing Superoxide-Dismutase Deficiency in...Adults with Rheumatoid Arthritis

    Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals.


  6. Manganese Superoxide Dismutase Gene Polymorphism and Schizophrenia

    There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia.


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Manganese has not been evaluated or approved by the FDA for the any of the following topics indicated in the links above: AIDS/HIV, diabetes, epilepsy, multiple sclerosis, osteoporosis, schizophrenia

Statements on this website have NOT been evaluated by the Food and Drug Administration and are NOT intended to diagnose, treat, cure, or prevent any disease; research is ongoing. All third-party health topic links provided on this website are for information purposes only. Always consult your doctor or nutritionist about any health or nutrition-related questions you might have.