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SYSTEMIC ENZYME FORMULAS

Systemic enzymes increase the enzyme levels throughout your body to assist in restoring the body to health.*

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ORIGINAL SYSTEMIC ENZYMES
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More About Enzymes
Enzymes are found in every cell of every living plant and animal, including humans. Enzymes are biocatalysts, which means that they either begin a reaction or cause a reaction to speed up. Without enzymes, life would not exist.

How Do Enzymes Work?
Enzymes work by virtue of their shape. An enzyme molecule can be compared, in shape at least, to many short strings of pearls (amino acids) strung together. This long string folds in on itself as certain sequences of amino acids (pearls) are more attracted to each other than to other sequences, thus giving the enzymes a specific shape. At one point, on the surface of this string of pearls there exists something which looks like a keyhole. This is called the "active site" on the enzyme. When matched with its specific coenzyme (a vitamin, mineral, or trace element) this "lock" has the exact inverse contour of the "key" which is contained in the molecule of the enzyme's "substrate" (the molecule that the enzyme wants to transform into a different molecule). When the substrate appears, it inserts the "key" into the "lock". The molecular structure of the substrate is transformed into a different molecular structure, and both enzyme and the newly transformed molecue go on their merry ways.

Vitamins are coenzymes and minerals are cofactors to enzymes. Enzymes are needed in the body for both of them to be able to have their full effect. In addition, the vitamins and minerals assist the enzymes. Systemic enzymes will enhances the effect of other supplementation programs.

The Different Types of Enzymes
Digestive enzyme breaks down the proteins, fats and carbohydrates in food during the digestive process, allowing the body to better utilize the food you eat. Proteolytic enzymes digest protein and are considered anti-inflammatory agents. Some examples of proteolytic enzymes are protease, serrapeptase, bromelain, and papain. Lipase enzymes digest fat. Amylase enzymes digest carbohydrates.
Systemic enzymes increase the enzyme levels throughout your body to assist in restoring the body to health.

Side Effects Noted With Systemic Enzymes
Those using anti-coagulants, or blood thinners, should not use systemic enzymes without the consent of their physician. The enzymes enhance the effects of the blood thinning medications, making them stronger. Do not take this product without the consent of your physician if you are currently taking anti-coagulants, commonly known as blood thinners.



More About Original Systemic Enzyme Blend
Original Systemic Enzyme Blend is a 100% vegetarian blend of Bromelain, Papain, Serrapeptase, Amylase, Lypase, and other enzymes that work synergistically together providing total system suport.

Systemic enzymes can help relieve inflammation, fibrosis (scar tissue), and viruses; modulate the immune system; and cleanse the blood. They differ from digestive enzymes (which conduct their actions in the stomach to digest food) in that they are enterically coated to prevent contact with the stomach acid so that they pass through the stomach into the intestines where they are absorbed by the body.

Serrapeptase is a paptidase that is used worldwide as an anti-inflammatory enzyme, replacing bovine derived trypsin and chymotrypsin. In addition to enzymes, Original Systemic Enzyme Blend is supplemented with Amla, found naturally in the gooseberry. This unique ingredient provides very synergistic support ot the enzymatic activity of Systemic Enzymes and is well known for its antioxidant properties. Original Systemic Enzyme Blend also contains Rutin, which is highly regarded as nature's super anti-oxidant.

The enzymes in Original Systemic Enzyme Blend come from two sources: the fruit enzymes, along with Amla and Rutin, are from fruit grown in organic plantations; and the protease and serrapeptase are lab grown in a protein (fungus) medium. The enzymes are then extracted from the medium so that not a trace of fungus is left on the enzyme and the purity is assured.

Original Systemic Enzyme Blend contains no animal derivatives, so even vegetarians can enjoy the benefits. It is produced with enterically coated enzymes, and its special formulation permits it to operate in an extremely wide pH range, allowing for better absorption. It is packaged with an easy open flip top cap, making in convenient for carpal tunnel and arthritis sufferers.

Proteolytic Enzyme (Protease)
The term "proteolytic" refers to all enzymes that digest protein. Other classes of enzymes include Amylase, a digestive enzyme that breaks down carbohydrates, and Lipase, a digestive enzyme that breaks down fat during the digestive process. Each of these help in the digestion of food, which in turn helps with absorption of those essential nutrients in the diet. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fungal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants (such as Papain from the papaya and Bromelain from pineapples). The primary uses of proteolytic enzymes in dietary supplements are used as digestive enzymes, anti-inflammatory agents, and pain relievers.

There are a number of clinical trials showing the benefit of using oral proteolytic enzymes as a digestive aid. Proteolytic enzymes are also theorized to help reduce symptoms of food allergies, and as a treatment for rheumatoid arthritis and other autoimmune diseases.

Perhaps the strongest evidence for benefits of proteolytic enzyme supplements come from numerous European studies showing various enzyme blends to be effective in accelerating recovery from exercise and injury in sportsmen as well as tissue repain in patients following surgery. In one study of footballers suffering from ankle injuries, proteolytic enzyme supplements accerlerated healing and got players back on the field about 50% faster than athletes assigned to receive a placebo tablet. 1 A handful of other small trials in athletes have shown enzymes can help reduce inflammation, speed healing of bruises and other tissue injuries (including fractures), and reduce overall recovery time when compared to athletes taking a placebo. 2-3 In patients recovering from facial and various reconstructive sugeries, treatment with proteolytic enzymes significantly reduced swelling, bruising and stiffness compared to placebo groups. 9-11

Serrapeptase
Serrapeptase, also known as Serratia peptidase, is a proteolytic enzyme isolated from the non-pathogenic enterobacteria Serratia E15. In Japan, it is a registered anti-inflammatory medicine sold under the product name Dasen®. Serrapeptase is laboratory grown. The enzyme is found naturally in the intestine of the silkworm, which is used by the silkworm to dissolve the cocoon and emerge as a moth. When consumed in unprotected tablets or capsules, the enzyme is destroyed by acid in the stomach. However, when enterically coated, the enzyme passes through the stomach unchanged and can be absorbed by the intestine.

It has many clinical uses, including as an anti-inflammatory agent (particularly for post traumatic swelling), for fibrocystic breast disease, and for bronchitis (serrapeptase loosens and expels mucous).

Serrapeptase digests dead tissue, blood clots, cysts, and arterial plaque. The late German physician Dr. Hans Nieper used serrapeptase to treat arterial blockage in his coronary patients. Clinical studies show that serrapeptase induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes. 12 Besides reducing inflammation, one of serrapeptase's most profound benefits is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues. 13 Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance, and are using it in treatment as an alternative to salicylates, ibuprofen, and other NSAIDS. 14

Bromelain and Papain
Both Bromelain and Papain are plant-derived proteolytic enzymes. Bromelain, also known as bromelin, is a protein-digesting enzyme extracted from the flesh and stem of the pineapple plant, Ananas Comosus. Papain is a proteolytic enzyme isolated from the papaya plant, Carica Papaya. Bromelain is most notable for its effectiveness in the reduction of inflammation and decreasing swelling, but the scope of its benefits continues to increase. As a natural anti-inflammatory enzyme, bromelain has many uses. Arthritis patients may reduce the swelling that causes joint pain by taking bromelain. Bromelain may also be helpful for the pain, numbness, tingling, aching and loss of motor and sensory function in the fingers resulting from carpal tunnel syndrome (CTS). 15, 16 Prevention of the adhesiveness of platelets to endothelial cell walls was accomplished with 0.1 mcg/ml of Bromelain. 16a Thus the benefti of bromelain occurs over a broad range of doses, and even small amounts may be beneficial to anyone at risk to thrombotic heart attack or stroke. Papain has been shown to be effective in preventing burn wound infection and helping remove dead cells. 17

Papain is also used for defibrinating wounds in hopitals, preventing cornea scar deformation, treating jellyfish and insect stings, treating edemas and inflammatory processes, accelerating wound healing, for indigestion, dissolving membranes in diphtheria, treating ulcers, and to reduce fever, swelling and adhesions after surgery.

Amla
Also known as Indian gooseberry (Emblica officinalis) is the richest source of Vitamin C. The Vitamin C in Amla is from the Rutin family, and there is about 50 mg per System Enzyme capsule. It also contains tannic acid, glucose, protein, cellulose and Calcium. Amla is useful for stomach problems, it is antipyretic, hair tonic and nerve brain tonic. It is also useful in anemia, hyperacidity and in gynecological problems and epistaxis. Amla is considered to have restorative and preventative properties.

Rutin
Rutin is one of the many existing Flavonoids, which are a class of water-soluble plant pigments. Flavonoids support health by strengthening capillaries and other connective tissue, and some function as anti-inflammatory, antihistaminic, and antiviral agents. Rutin and several other flavonoids may also protect blood vessels. Rutin was shown to stimulate wound healing in rats and augment the tensile strength of scar tissue significantly. 18

References
1) Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract. 1970 Sep;24(9):375-7
2) Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury. 1975 May;6(4):313-6
3) Fisher JD, Weeks RL, Curry WM, Hrinda ME, Rosen LL. Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man. J Med. 1974;5(5):258-73
4) France LH. Treatment of injuries with orally administered Varidase as compared to Chymoral and Tanderil. Praxis. 1968 May 14;57(19):683-5
5) Gal P, Ted F, Skotakova J, Mach V. Systemic enzyme therapy in the treatment of supracondylar fractures of the humerus in children. Rozhi Chir. 1998 Dec;77912):574-6
6) Hingorani K. Oral enzyme therapy in severe back pain. Br J Clin Pract. 1968 May 5;22(5):209-10
7) Rathgeber WF. The use of proteolytic enzymes (chymoral ) in sporting injuries. S Afr Med J. 1971 Feb 13;45(7):181-3
8) Schwinger O. Results of oral enzyme therapy in wounds of muscles, tendons and bones after accidents. Wien Med Wochenschr. 1970 Sep 5;120(36):603-5
9) Duskova M, Wald M. Orally administered proteases in aesthetic surgery. Aesthetic Plat Surg. 1999 Jan-Feb;23(1):41-4
10) Hoemecke R, Doenicke A. Perioperative enzyme theapy. A significant supplement to postoperative pain therapy? Anaesthesist. 1993 Dec;42(12):856-61
11) Lie KK, Larsen RD, Posch JL. Therapeutic value of oral proteolytic enzymes following hand surgery. Arch Surg. 1969 Jan;98(1):103-4
12) Mazzone A, Catalani M, Constanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngolog pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990,18(5):379-88
13) Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngolog pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990,18(5):379-88
14) Aso T, et al. Breast engorgement and its treatment: Clinical effects of Danzen, an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981;33:371-9
15) Petry, Judy J. "Nutritional supplements and surgical patients" AORN Journal (June 1997)
16) Kelly, G.S. "Bromelain: A Literature Review and Discussion of Its Therapeutic Applications." Alternative Medicine Review (November 1, 1996).
16a) Metzig, C et al Bromelain Proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo 13(1):7-12 Jan-Feb 1999
17) Starley, I.F.; Mohammed, P.; Schneider, G.; Bickler, SW. The treatment of peadiatric burns using topical papaya. Burns 1999 Nov 25(7)636-9
18) Wilhelmi, G. Effect of O-(beta-hydroxyelthyl)-rutiside on wound healing in the rat. J Pharmacology 1979;19(2):82-5



More About 10Zymes Advanced Fibrin Defense
10Zymes is a proprietary combination of pharmaceutical grade enzyme components in an emulsifed form specially formulated to assist and defend your body from the damaging effects of fibrin. As fibrin build up in our bodies, it may cause many unhealthy conditions. 10Zymes can help keep fibrin and its harmful results under control.

Enzyme potency is measured in activity levels, measured by FU's or fibrinolytic units. Average enzyme blends contain 1,000 to 2,000 FU's. 10Zymes contains 15,000 FU's per serving. 10Zymes can be used with other dietary supplements.

10Zymes Advanced Fibrin Defense can be beneficial for scar tissue removal, immune system function, viral immunity, pain relief, blood clotting, thrombus removal, arthritic conditions, reduction of inflammation and blood cleansing, among other uses.



ENZYME FORMULA COMPARISON CHART (per capsule)
PRODUCTS
SYSTEMIC
ENZYMES
10ZYMES
AMLA
AMYLASE
BROMELAIN
COQ10
LIPASE
MAGNESIUM
NATTOKINASE
PAPAIN
PROTEASE
RUTIN
SEBKINASE
SERRAPEPTASE / SERRATIOPEPTIDASE
PRODUCTS
SYSTEMIC
ENZYMES
10ZYMES



LINK INFORMATION DISCLAIMER
The information links provided below are not intended to promote a particular product. These links are intended to provide a broad overview of various research and hypothesis on the role of minerals and nutrition in health. They are provided to encourage personal research and a balanced view on various health and nutrition topics.
Unless noted, the articles below do NOT include scientific references.

MORE INFORMATION ABOUT ENZYMES
01. Food Enzymes: The First Line of Defense...
Research shows that protein digesting enzymes can dissolve the protein coating from around cancer cells, and this enables white blood cells (which are part of the immune system) to destroy the cancer cells. Article by Mauris Emeka, author of Cancer’s Best Medicine and Fear Cancer No More.
02. Low Enzyme Levels Linked to Chemical Intolerance...
If one has a much lower level than normal of the enzymes involved in detoxification of any given stimuli , then one will have a lower tolerance to the stimuli.
03. What Are Systemic Enzymes and What Do They Do?...
The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ.
04. Enzymes, Spider Veins and Scar Tissue...
Enzymes strengthen blood vessel walls and open micro circulation passages clogged with fibrin improving circulation overall. Enzymes also control the rate and accuracy of healing. They speed healing without allowing the build up of scar tissue. 
05. Finding Your Enzyme Activation Dose...
An activation dose is the amount of enzymes you need to begin to feel a benefit. 
06. Diabetes and Enzymes...
The use of enzymes could decrease the need for insulin in diabetics.
07. Enzymes and Athletics...
Most every European Olympic team uses systemic proteolytic enzymes, as do most all of the European sports teams.
08. Systemic Enzymes and Detox Reactions...
Many don't realize that the enzymes can also help the liver to get rid of the toxins it's been holding onto. 
09. Pancreatic Enzyme Extract Improves Survival in Murine Pancreatic Cancer...
Oral Proteolitic Enzyme Therapy on Rat Mammary Tumors...
Evaluation of Pancreatic Proteolytic Enzyme Treatment...
Scientific studies using enzymes in cancer research.
10. The Condensed Enzyme Fact Reference...
Contains information on the many aspects of enzymes.



*Statements on this website have NOT been evaluated by the Food and Drug Administration and are NOT intended to diagnose, treat, cure, or prevent any disease; research is ongoing. The information provided on this website comes from a variety of online sources. Please refer to the "More Information On..." links near the bottom of each of our website pages to view these information sources. READ FULL DISCLAIMER HERE



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