|
MORE INFORMATION ABOUT URSOLIC ACID
|
|
|
Essense-of-Life.com encourages personal research and a balanced view of health and nutrition topics. The information links below are intended to provide a broad overview of various research findings and hypothesis on the role of nutrition in health. This information is not intended to promote any particular product.
Unless noted, the articles below may NOT include any scientific references or sources.
|
|
|
01.
|
Pharmacology of Oleanolic Acid and Ursolic Acid |
|
Ursolic acid is a compound that exists widely in food, medicinal herbs and other plants. Ursolic acid is relatively non-toxic and has been used in cosmetics and health products. Recent scientific research has noted ursolic acid's antitumor-promotion effects.
SCIENTIFIC ARTICLE |
|
|
02.
|
Ursolic Acid: Phytochemical |
|
Ursolic acid is present in many plants, including apples, bilberries, cranberries, elder flower, peppermint, lavender, oregano, thyme, hawthorn, prunes. Ursolic acid has antibacterial and antifungal activity. Tests have shown that Ursolic acid inhibits the growth of Candida albicans and Microsporium lenosum. Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns. Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth. |
|
|
03.
|
Inhibition of Tumor Promotion in Skin |
|
Topical cosmetic preparations containing ursolic acid / oleanolic acid have been patented in Japan for the prevention of topical skin cancer.
INCLUDES REFERENCES |
|
|
04.
|
Antitumour Effects of Ursolic Acid Isolated From Oldenlandia Diffusa |
|
Ursolic acid demonstrated a significant inhibition of the proliferation of cultured tumour cells.
SCIENTIFIC STUDY |
|
|
05.
|
Antibacterial Effects of Ursolic Acid Against Cariogenic Bacteria |
|
Ursolic acid is present in the leaf of loquat and the calyx of persimmon, which have been used as toothpicks since ancient times in Japan. In this study...dental caries scores were significantly decreased in the group given Ursolic acid. Ursolic acid can be used in preventional food additives against dental caries.
SCIENTIFIC STUDY |
|
|
06.
|
Ursolic Acid Regulates High Glucose-Induced Apoptosis |
|
A high concentration of glucose has been implicated as a causal factor in initiation and progression of diabetic complications and that hyperglycemia increases the production of free radicals and oxidative stress. Compounds that scavenge reactive oxygen species may confer regulatory effects on high glucose-induced apoptosis. Ursolic acid is reported to have an antioxidant activity. Ursolic acid may play an important role in regulating the apoptosis induced by high glucose presumably through scavenging of reactive oxygen species.
SCIENTIFIC STUDY |
|
|
07.
|
Anabolic Activity of Ursolic Acid in Bone: Stimulating Osteoblast Differentiation In Vitro and Inducing New Bone Formation In Vivo |
|
Ursolic acid was shown to have bone-forming activity in vivo in a mouse calvarial bone formation model. These results suggested that ursolic acid has the anabolic potential to stimulate osteoblast differentiation and enhance new bone formation.
SCIENTIFIC STUDY |
|
| 08. |
Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols |
|
The treatment of cancer with chemotherapeutic agents and radiation has two major problems: tumor resistance to therapy and toxicity toward normal cells. Recent research has suggested that plant polyphenols (which includes ursolic acid) might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. These agents have also been found to be protective from therapy-associated toxicities.
SCIENTIFIC STUDY |
|
| 09. |
Role of Chemopreventive Agents in Cancer Therapy |
|
Extensive research in the last few years has revealed that regular consumption of certain fruits and vegetables can reduce the risk of acquiring specific cancers. Phytochemicals derived from such fruits and vegetables, referred to as chemopreventive agents include ursolic acid. These agents have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit NF-kappaB, AP-1 and JAK-STAT activation pathways, inhibit angiogenesis, suppress the expression of anti-apoptotic proteins and inhibit cyclooxygenase-2. These chemopreventive agents also have very recently been found to reverse chemoresistance and radioresistance in patients undergoing cancer treatment. Thus, these chemopreventive agents have potential to be used as adjuncts to current cancer therapies.
SCIENTIFIC STUDY |
|
| 10. |
From Chemoprevention to Chemotherapy: Common Targets and Common Goals |
|
Cancer is a multifactorial disease that requires modulation of multiple pathways and multiple targets. Various molecular targets of chemoprevention (the abrogation or delay in the onset of cancer) are also relevant to the therapy of cancer. These targets include the activation of apoptosis; suppression of growth factor expression or signalling; and downregulation of angiogenesis through inhibition of vascular endothelial growth factor expression. Pharmacologically safe phytochemicals (including ursolic acid) have been identified from plants or their variant forms that can modulate these molecular targets. These phytochemicals also can reverse chemoresistance and radioresistance. Because of their pharmacological safety, these agents can be used alone to prevent cancer and in combination with chemotherapy to treat cancer.
SCIENTIFIC STUDY |
|
| 11. |
Enhancement of Chemotherapeutic Agent-Induced Apoptosis...Using Ursolic Acid |
|
By supplementing chemotherapy with minimally toxic ursolic acid, it is possible to improve the efficacy of cancer treatment by significantly reducing the necessary drug dose without sacrificing the treatment results. CNF-kappaB activation is known to reduce the efficiency of chemotherapy in cancer treatment. Ursolic acid, a minimally toxic compound, has shown the capability to inhibit NF-kappaB activation in living cells. Ursolic acid-mediated suppression of NF-kappaB drastically reduced the required dosage of the chemotherapeutic agents to achieve identical biological endpoints and enhanced the chemotherapeutic agent-induced cancer cells apoptosis. Prolonged treatment with relatively low doses of ursolic acid also sensitized cancer cells to the chemotherapeutic agents through suppression of NF-kappaB.
SCIENTIFIC STUDY |
|
| 12. |
New Chemoprotective Compounds |
|
Ursolic acid and oleanolic acid are pentacyclic triterpenoic acids...Both compounds have been shown to act at various stages of tumor development, including inhibition of tumorigenesis, inhibition of tumor promotion, and induction of tumor cell differentiation. They effectively inhibit angiogenesis, invasion of tumor cells and metastasis.
SCIENTIFIC STUDY |
|
| 13. |
Antigenotoxic Effects of Quercetin, Rutin and Ursolic Acid on HepG2 Cells |
|
The results show that quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. Quercetin and ursolic acid also showed to increase the rate of DNA repair. These results, obtained with liver cells, emphasize and confirm the chemopreventive potential of quercetin and ursolic acid, which may help explain the lower cancer incidence in human population with high dietary intakes of fruits and vegetables.
SCIENTIFIC STUDY |
|
|
Key words for internet research: ursolic acid and sage extract, ursolic acid and oleaonolic acid, ursolic acid and anti-tumor, ursolic acid and candida, ursolic acid and anti-inflammatory, ursolic acid and skin cancer, ursolic acid and dental caries, ursolic acid and diabetes, ursolic acid and bone, ursolic acid and anabolic, ursolic acid supplement, ursolic acid dietary supplement
|
