ENZYMES

Original Systemic Enzyme Blend
• Why Take Sytemic Enzymes
• Facts about Original Systemic Enzyme Blend
• Original Systemic Enzyme Blend Ingredients
• What Are Systemic Enzymes and What Do They Do
• How Much to Systemic Enzyme Blend To Take
• Systemic Enzymes and Detox Reactions

10Zymes Natural Fibrin Defense
• 10Zymes Advanced Fibrin Defense Information

More Information
• Enzyme FAQ
• Enzyme Information Links

Why Take Systemic Enzymes?

Digestive Enzymes vs. Systemic Enzymes
Digestive enzymes conduct their actions in the stomach to digest food while systemic enzymes are enterically coated to prevent contact with the stomach acid. This way they pass through the stomach into the intestines where they are absorbed by the body.

The primary function of systemic enzymes
Systemic enzymes fight inflammation, fibrosis (scar tissue), and viruses; modulate the immune system; and cleanse the blood.


Facts about Systemic Enzymes
Systemic Enzymes is a 100% vegetarian blend of Bromelain, Papain, Serrapeptase, Amylase, Lypase, and other enzymes that work synergistically together providing total system suport.

Serrapeptase is a paptidase that is used worldwide as an anti-inflammatory enzyme, replacing bovine derived trypsin and chymotrypsin. In addition to enzymes, Systemic Enzymes is supplemented with Amla, found naturally in the gooseberry. This unique ingredient provides very synergistic support ot the enzymatic activity of Systemic Enzymes and is well known for its antioxidant properties. Systemic Enzymes also contains Rutin, which is highly regarded as nature's super anti-oxidant.

Systemic Enzymes contains no animal derivatives, so even vegetarians can enjoy the benefits. It is produced with enterically coated enzymes, and its special formulation permits it to operate in an extremely wide pH range, allowing for better absorption. It is packaged with an easy open flip top cap, making in convenient for carpal tunnel and arthritis sufferers.


Original Systemic Enzyme Blend Ingredients

Proteolytic Enzyme (Protease)
The term "proteolytic" refers to all enzymes that digest protein. Other classes of enzymes include Amylase, a digestive enzyme that breaks down carbohydrates, and Lipase, a digestive enzyme that breaks down fat during the digestive process. Each of these help in the digestion of food, which in turn helps with absorption of those essential nutrients in the diet. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fngal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants (such as papain from the papaya and Bromelain from pineapples). The primary uses of proteolytic enzymes in dietary supplements are used as digestive enzymes, anti-inflammatory agents, and pain relievers.

There are a number of clinical trials showing the benefit of using oral proteolytic enzymes as a digestive aid. Proteolytic enzymes are also theorized to help reduce symptoms of food allergies, and as a treatment for rheumatoid arthritis and other autoimmune diseases.

Perhaps the strongest evidence for benefits of proteolytic enzyme supplements come from numerous European studies showing various enzyme blends to be effective in accelerating recovery from exercise and injury in sportsmen as well as tissue repain in patients following surgery. In one study of footballers suffering from ankle injuries, proteolytic enzyme supplements accerlerated healing and got players back on the field about 50% faster than athletes assigned to receive a placebo tablet. ₁ A handful of other small trials in athletes have shown enzymes can help reduce inflammation, speed healing of bruises and other tissue injuries (including fractures), and reduce overall recovery time when compared to athletes taking a placebo. _2-3 In patients recovering from facial and various reconstructive sugeries, treatment with proteolytic enzymes significantly reduced swelling, bruising and stiffness compared to placebo groups. _9-11

Serrapeptase
Serrapeptase, also known as Serratia peptidase, is a proteolytic enzyme isolated from the non-pathogenic enterobacteria Serratia E15. The enzyme is found naturally in the intestine of the silkworm, which is used by the silkworm to dissolve the cocoon and emerge as a moth. When consumed in unprotected tablets or capsules, the enzyme is destroyed by acid in the stomach. However, when enterically coated, the enzyme is destroyed by acid in the stomach. However, when enterically coated, the enzyme passes through the stomach unchanged and can be absorbed by the intestine.

It has many clinical uses, including as an anti-inflammatory agent (particularly for post traumatic swelling), for fibrocystic breast disease, and for bronchitis (serrapeptase loosens and expels mucous).

Serrapeptase digests dead tissue, blood clots, cysts, and arterial plaque. The late German physician Dr. Hans Nieper used serrapeptase to treat arterial blockage in his coronary patients. Clinical studies show that serrapeptase induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes. ₁₂ Besides reducing inflammation, one of serrapeptase's most profound benefits is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues. ₁₃ Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance, and are using it in treatment as an alternative to salicylates, ibuprofen, and other NSAIDS. ₁₄

Bromelain and Papain
Both Bromelain and Papain are plant-derived proteolytic enzymes. Bromelain, also known as bromelin, is a protein-digesting enzyme extracted from the flesh and stem of the pineapple plant, Ananas Comosus. Papain is a proteolytic enzyme isolated fromthe papaya plant, Carica Papaya. Bromelain is most notable for its effectiveness in the reduction of inflammation and decreasing swelling, but the scope of its benefits continues to increase. As a natural anti-inflammatory enzyme, bromelain has many uses. Arthritis patients may reduce the swelling that causes joint pain by taking bromelain. Bromelain may also be helpful for the pain, numbness, tingling, aching and loss of motor and sensory function in the fingers resulting from carpal tunnel syndrome (CTS). _{15, 16} Prevention of the adhesiveness of platelets to endothelial cell walls was accomplished with 0.1 mcg/ml of Bromelain. _16a Thus the benefti of bromelain occurs over a broad range of doses, and even small amounts may be beneficial to anyone at risk to thrombotic heart attack or stroke. Papain has been shown to be effective in preventing burn wound infection and helping remove dead cells. ₁₇

Papain is also used for defibrinating wounds in hopitals, preventing cornea scar deformation, treating jellyfish and insect stings, treating edemas and inflammatory processes, accelerating wound healing, for indigestion, dissolving membranes in diphtheria, treating ulcers, and to reduce fever, swelling and adhesions after surgery.

Amla
Also known as Indian gooseberry (Emblica officinalis) is the richest source of Vitamin C. The Vitamin C in Amla is from the Rutin family, and there is about 50 mg per System Enzyme capsule. It also contains tannic acid, glucose, protein, cellulose and Calcium. Amla is useful for stomach problems, it is antipyretic, hair tonic and nerve brain tonic. It is also useful in anemia, hyperacidity and in gynecological problems and epistaxis. Amla is considered to have restorative and preventative properties.

Rutin
Rutin is one of the many existing Flavonoids, which are a class of water-soluble plant pigments. Flavonoids support health by strengthening capillaries and other connective tissue, and some function as anti-inflammatory, antihistaminic, and antiviral agents. Rutin and several other flavonoids may also protect blood vessels. Rutin was shown to stimulate wound healing in rats and augment the tensile strength of scar tissue significantly. ₁₈


How Much To Take?
By William Wong, N.D., Ph.D., Member World Sports Medicine Hall of Fame

Finding Your "Activation" Dose
When Systemic Enzymes "kick in", there will be no doubt in your mind that they are working! An activation dose is the amount of enzymes you need to begin to feel a benefit from the product. The recommended dosage given onthe label is meant as a maintenance dose for those without any complaints. Consumers with fibromyalgia, Chronic Fatigue, Arthritis, Auto Immune conditions, or Fibrosis complaints and Inflammation symptoms need to find the dose at which they begin to feel better. They can then maintain that dose, or after 3 months, try to reduce the dose to see if the benefits are still felt.

Start taking 3 capsules 3 times a day, in-between meals. If in 3 days, no benefits are felt, increase the dose to 4 capsules 3 times a day for 3 days. Continue increasing the number of capsules taken until a benefit is felt. Most will feel the Systemic Enzymes kick in somewhere between 3 and 5 capsules, 3 times a day.

There is no toxicity from enzymes, (no LD-50). some customers who have suffered accidents have been placed on 10 capsules 3 times a day by there doctors for a few weeks until the bulk of their inflammation and its resultant pain are gone. Then they are brought down to a much lower maintenance dose to prevent the formation of scar tissue.

Hemophiliacs and those on prescription blood thinners should not use this or any other systemic enzymes as the enzymes help the drugs to work better and may overly thin the blood.

NOTE: The Food and Drug Administration has not evaluated the above information. This product or the listed information is not intended to diagnose, treat, cure or prevent disease. For all conditions or illnesses see a health professional for a full evaluation, diagnosis and treatment plan.


Systemic Enzymes and Detox Reactions
By William Wong, N.D., Ph.D., Member World Sports Medicine Hall of Fame

Systemic enzymes have many and varied uses. Most folks are now familiar with the controlling of inflammation, fibrosis and the like, but many don't realize that the enzymes can also help the liver to get rid of the toxins it's been holding onto.

Our livers are the filters of the body. They remove toxic material and either release it into the colon for disposal or store the toxins in the fat cells of the liver. If the liver's fat cells are already overburdened with toxins then the organ will create fat cells elsewhere inthe body to store the toxins in. Most folks who have never had a liver detox reaction or done a purposeful liver detox have bits of toxic material from pollution, medication and "recreational" drug use socked away in their livers that has been building up their entire life.

A few natural therapies can cause the liver to "dump" its store of held toxins: colon hydrotherapy, green foods and drinks which are high in sulfur, fasting, and systemic enzyme use.

When liver detox reactions happen, they are in fact good things, though at times the process does not feel good. Feelings of having a body flu, headache, nausea, skin rash, bad breath or body odor can occur. If narcotic or hallucinogenic drug use has been part of the patient's history then sometimes, as the tiny bits of those substances are released into the blood stream for disposal, symptoms of being on the drugs may once again occur.

The bad feelings develop as a result of the colon not being able to get rid of the toxins as fast as the liver excretes them. All detox reactions should be expedited to assist the body in getting rid of the toxins. The following can be done: use of a natural liver-cleansing agent as those available in health food stores, use of colon hydrotherapy, increasing the ingestion of green foods and drinks, increasing water intake, and increasing magnesium intake to over 2,000 mg a day. In addition, decreasing the amount of enzymes being supplemented can slow the rate of detox.

Liver detoxing reactions are a beneficial cleansing for the body. They might not feel great while we're going through them, but it will help us to have squeaky-clean insides.

NOTE: The Food and Drug Administration has not evaluated the above information. This product or the listed information is not intended to diagnose, treat, cure or prevent disease. For all conditions or illnesses see a health professional for a full evaluation, diagnosis and treatment plan.



References
1) Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract. 1970 Sep;24(9):375-7

2) Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury. 1975 May;6(4):313-6

3) Fisher JD, Weeks RL, Curry WM, Hrinda ME, Rosen LL. Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man. J Med. 1974;5(5):258-73

4) France LH. Treatment of injuries with orally administered Varidase as compared to Chymoral and Tanderil. Praxis. 1968 May 14;57(19):683-5

5) Gal P, Ted F, Skotakova J, Mach V. Systemic enzyme therapy in the treatment of supracondylar fractures of the humerus in children. Rozhi Chir. 1998 Dec;77912):574-6

6) Hingorani K. Oral enzyme therapy in severe back pain. Br J Clin Pract. 1968 May 5;22(5):209-10

7) Rathgeber WF. The use of proteolytic enzymes (chymoral ) in sporting injuries. S Afr Med J. 1971 Feb 13;45(7):181-3

8) Schwinger O. Results of oral enzyme therapy in wounds of muscles, tendons and bones after accidents. Wien Med Wochenschr. 1970 Sep 5;120(36):603-5

9) Duskova M, Wald M. Orally administered proteases in aesthetic surgery. Aesthetic Plat Surg. 1999 Jan-Feb;23(1):41-4

10) Hoemecke R, Doenicke A. Perioperative enzyme theapy. A significant supplement to postoperative pain therapy? Anaesthesist. 1993 Dec;42(12):856-61

11) Lie KK, Larsen RD, Posch JL. Therapeutic value of oral proteolytic enzymes following hand surgery. Arch Surg. 1969 Jan;98(1):103-4

12) Mazzone A, Catalani M, Constanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngolog pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990,18(5):379-88

13) Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngolog pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990,18(5):379-88

14) Aso T, et al. Breast engorgement and its treatment: Clinical effects of Danzen, an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981;33:371-9

15) Petry, Judy J. "Nutritional supplements and surgical patients" AORN Journal (June 1997)

16) Kelly, G.S. "Bromelain: A Literature Review and Discussion of Its Therapeutic Applications." Alternative Medicine Review (November 1, 1996).

16a) Metzig, C et al Bromelain Proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo 13(1):7-12 Jan-Feb 1999

17) Starley, I.F.; Mohammed, P.; Schneider, G.; Bickler, SW. The treatment of peadiatric burns using topical papaya. Burns 1999 Nov 25(7)636-9

18) Wilhelmi, G. Effect of O-(beta-hydroxyelthyl)-rutiside on wound healing in the rat. J Pharmacology 1979;19(2):82-5


10Zymes Advanced Fibrin Defense Information
10Zymes is a proprietary combination of pharmaceutical grade enzyme components in an emulsifed form specially formulated to assist and defend your body from the damaging effects of fibrin. As fibrin build up in our bodies, it may cause many unhealthy conditions. 10Zymes can help keep fibrin and its harmful results under control.

Enzyme potency is measured in activity levels, measured by FU's or fibrinolytic units. Average enzyme blends contain 1,000 to 2,000 FU's. 10Zymes contains 15,000 FU's per serving. 10Zymes can be used with other dietary supplements.

10Zymes Advanced Fibrin Defense can be beneficial for scar tissue removal, immune system function, viral immunity, pain relief, blood clotting, thrombus removal, arthritic conditions, reduction of inflammation and blood cleansing, among other uses.

Recommended dosage is 1 capsule 3 times a day on an empty stomach.